Genome‐wide allele‐ and strand‐specific expression profiling
نویسندگان
چکیده
منابع مشابه
Genomewide expression profiling of cryptolepine-induced toxicity in Saccharomyces cerevisiae.
We have used the budding yeast Saccharomyces cerevisiae to identify genes that may confer sensitivity in vivo to the antimalarial and cytotoxic agent cryptolepine. Five S. cerevisiae strains, with different genetic backgrounds in cell permeability and DNA damage repair mechanisms, were exposed to several concentrations of cryptolepine. Cryptolepine showed a relatively mild toxicity for wild-typ...
متن کاملDirect-to-consumer genomewide profiling.
n engl j med 364;21 nejm.org may 26, 2011 2074 controls in the genomic regions we presented, on the SNP level as evidenced by the basic allele test, and on the allele level as evidenced by the haplotype association test (Fig. 2 of our article). Imputation of classic HLA alleles, which in general are determined by appreciation of known variants only, may lead to rare alleles being missed or impu...
متن کاملGenome-wide allele- and strand-specific expression profiling
Recent reports have shown that most of the genome is transcribed and that transcription frequently occurs concurrently on both DNA strands. In diploid genomes, the expression level of each allele conditions the degree to which sequence polymorphisms affect the phenotype. It is thus essential to quantify expression in an allele- and strand-specific manner. Using a custom-designed tiling array an...
متن کاملRegulatory divergence in Drosophila melanogaster and D. simulans, a genomewide analysis of allele-specific expression.
Species-specific regulation of gene expression contributes to the development and maintenance of reproductive isolation and to species differences in ecologically important traits. A better understanding of the evolutionary forces that shape regulatory variation and divergence can be developed by comparing expression differences among species and interspecific hybrids. Once expression differenc...
متن کاملHLA and genomewide allele sharing in dizygotic twins.
Gametic selection during fertilization or the effects of specific genotypes on the viability of embryos may cause a skewed transmission of chromosomes to surviving offspring. A recent analysis of transmission distortion in humans reported significant excess sharing among full siblings. Dizygotic (DZ) twin pairs are a special case of the simultaneous survival of two genotypes, and there have bee...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2009
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb.2009.31